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The Fox Lab at Duke University
GENOMIC EXTREMES
IN ORGAN DEVELOPMENT, REGENERATION,
AND DISEASE
Polyploidy in
organ reGENERATION
The tissue regeneration field has made great strides in understanding how division of stem cells can restore injured organs. However, emerging evidence suggests many tissues rely on non-stem cell mechanisms to restore tissue mass after injury. Polyploidy can restore tissue mass by increasing cell size (hypertrophy). In addition to our work on the Drosophila hindgut, injuring the adult Drosophila abdominal and ovarian follicle epithelia causes polyploidization/hypertrophy. 30% resection of the liver, arguably the most highly regenerative mammalian organ, results in full tissue mass restoration exclusively by hypertrophy. READ MORE
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Generous Funding for this work provided by:
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